depression

Your gut microbiome influences your brain through the vagus nerve, immune signaling, and microbial chemistry. Here is what the mechanisms, the animal work, and the human trials actually show, and where the evidence stops.

The Default Mode Network activates when you're not focused on the world. What it is, what it does, and why depression, Alzheimer's, and psychedelics all touch it.

How psilocybin acts on the brain: 5-HT2A receptors, the default mode network, plasticity, and what clinical trials in depression, PTSD, and addiction show.

Depression is more than low serotonin. A look at the brain biology behind it: the serotonin debate, stress hormones, inflammation, neuroplasticity and new treatments.

Video games are increasingly recognized as tools for mental wellness. From anxiety management to therapy, gaming provides benefits science is only beginning to understand.

The US has the highest rate of depression and anxiety in OECD surveys. Australia and New Zealand lead in mental health spending per capita. Only 1 in 3 people with mental illness globally receive treatment. The mental health treatment gap costs the global economy $1 trillion per year in lost productivity.

About 1 in 7 people worldwide live with a mental disorder. The biology is real but incompletely understood, and several effective treatments exist. Here is what the evidence supports.